产品货号：
Z28710
中文名称：
TOCA-1/FNBP1L抗体
英文名称：
Anti-TOCA-1/FNBP1L Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TOCA-1/FNBP1L Antibody |
| 指标别名 | TOCA1,C1orf39,TOCA1,Formin-binding protein 1-like,Transducer of Cdc42-dependent actin assembly protein 1,Toca-1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | FNBP1L |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | TOCA-1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human TOCA-1.The immunogen is located within the last 50 amino acids of TOCA-1. |
| 计算分子量 | 70kDa |
| 成分 | TOCA-1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | TOCA-1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Actin reorganization is important for the regulation of neuronal morphology.A protein involved in this process,the transducer of cdc42-dependent actin assembly 1 (TOCA-1) protein,a member of the evolutionarily conserved pombe CDC15 homology (PCH) protein family,is an essential component of the Cdc42 pathway.TOCA-1 binds both N-WASP and Cdc42 and is essential for Cdc42- and PIP2-induced actin polymerization,suggesting that TOCA-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex.Decreased expression of TOCA-1 significantly enhances neurite elongation in PC-12 cells;its overexpression in the same cells suppresses neurite elongation.It has been suggested that TOCA-1 negatively regulates axon branching by regulating membrane trafficking by regulating membrane trafficking through the F-BAR/EFC domain.Multiple isoforms of TOCA-1 are known to exist. |
| Uniprot ID | Q5T0N5 |
| 基因名全称 | Formin binding protein 1-like |
| 蛋白名全称 | Formin binding protein 1-like |
| 推荐稀释比 | TOCA-1 antibody can be used for detection of TOCA-1 by Western blot at 1μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in mouse samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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